TGFβ signaling and the control of myofibroblast differentiation: Implications for chronic inflammatory disorders.
File(s)
Accepted version
Author(s)
Carthy, JM
Type
Journal Article
Abstract
The myofibroblast is a highly specialized cell type that plays a critical role during normal tissue wound healing, but also contributes pathologically to chronic inflammatory conditions such as fibrosis and cancer. As fibrotic conditions continue to be a major burden to the public health system, novel therapies that target the function of myofibroblasts may show promise in the clinic. The cytokine transforming growth factor β (TGFβ) is the most potent known inducer of myofibroblast differentiation and thus represents a powerful target to modify myofibroblast function during disease. This review focuses on our current understanding of the key signaling pathways activated by TGFβ during myofibroblast differentiation.
Date Issued
2017-05-15
Date Acceptance
2017-02-27
Citation
Journal of Cellular Physiology, 2017, 233 (1), pp.98-106
ISSN
1097-4652
Publisher
Wiley
Start Page
98
End Page
106
Journal / Book Title
Journal of Cellular Physiology
Volume
233
Issue
1
Copyright Statement
© 2017 Wiley Periodicals, Inc. This is the accepted version of the following article: Carthy JM. TGFβ signaling and the control of myofibroblast differentiation: Implications for chronic inflammatory disorders. J Cell Physiol. 2017; 9999:1–9. https://doi.org/10.1002/jcp.25879, which has been published in final form at https://dx.doi.org/10.1002/jcp.25879
Subjects
cancer
fibroblast
fibrosis
myofibroblast
smooth muscle α-actin
transforming growth factor β
1116 Medical Physiology
Biochemistry & Molecular Biology
Publication Status
Published