A P300-based cognitive assessment battery
File(s)
Published version
Author(s)
Kirschner, A
Cruse, D
Chennu, S
Owen, A
Hampshire, A
Type
Journal Article
Abstract
Background: It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitive processes. Methods: Here, we develop a series of EEG paradigms that probe several core aspects of cognition at the bedside without the need for motor responses and explore the sensitivity of this approach in a group of healthy controls. Results: Using analysis of ERPs alone, this method can determine with high reliability whether individual participants are able to attend a stimulus stream, maintain items in working memory, or solve complex grammatical reasoning problems. Conclusion: We suggest that this approach could form the basis of a brain-based battery for assessing higher cognition in patients with severe motor impairments or disorders of consciousness.
Date Issued
2015-04-23
Date Acceptance
2015-02-25
Citation
Brain and Behavior, 2015, 5 (6)
ISSN
2162-3279
Publisher
Wiley
Journal / Book Title
Brain and Behavior
Volume
5
Issue
6
Copyright Statement
© 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Publication Status
Published
Article Number
e00336