Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
File(s)
Accepted version
Author(s)
Demenais, Florence
Margaritte-Jeannin, Patricia
Barnes, Kathleen C
Cookson, William OC
Altmüller, Janine
Type
Journal Article
Abstract
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
Date Issued
2017-12-22
Date Acceptance
2017-11-08
Citation
Nature Genetics, 2017, 50 (1), pp.42-53
ISSN
1061-4036
Publisher
Nature Publishing Group
Start Page
42
End Page
53
Journal / Book Title
Nature Genetics
Volume
50
Issue
1
Copyright Statement
Copyright © 2017, Springer Nature
Sponsor
Medical Research Council (MRC)
National Institute for Health Research
Wellcome Trust
Medical Research Council (MRC)
Identifier
PII: 10.1038/s41588-017-0014-7
Grant Number
MR/K002449/1
NF-SI-0515-10016
096964/Z/11/Z
MR/K002449/2
Subjects
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
GENOME-WIDE ASSOCIATION
AUTOIMMUNE-DISEASE
HAY-FEVER
VARIANTS
METAANALYSIS
EXPRESSION
GENE
POPULATIONS
TWINS
Alleles
Asthma
Enhancer Elements, Genetic
Epigenesis, Genetic
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Histone Code
Humans
Leukocytes
Phenotype
Promoter Regions, Genetic
Rhinitis, Allergic, Seasonal
Risk
Australian Asthma Genetics Consortium (AAGC) collaborators
Leukocytes
Humans
Asthma
Genetic Predisposition to Disease
Risk
Epigenesis, Genetic
Histone Code
Phenotype
Alleles
Rhinitis, Allergic, Seasonal
Enhancer Elements, Genetic
Promoter Regions, Genetic
Genome-Wide Association Study
Genetic Loci
06 Biological Sciences
11 Medical and Health Sciences
Developmental Biology
Publication Status
Published
Date Publish Online
2017-12-22