Control mechanisms for stochastic biochemical systems via computation of reachable sets.
Author(s)
Lakatos, E
Stumpf, MPH
Type
Journal Article
Abstract
Controlling the behaviour of cells by rationally guiding molecular processes is an overarching aim of much of synthetic biology. Molecular processes, however, are notoriously noisy and frequently nonlinear. We present an approach to studying the impact of control measures on motifs of molecular interactions that addresses the problems faced in many biological systems: stochasticity, parameter uncertainty and nonlinearity. We show that our reachability analysis formalism can describe the potential behaviour of biological (naturally evolved as well as engineered) systems, and provides a set of bounds on their dynamics at the level of population statistics: for example, we can obtain the possible ranges of means and variances of mRNA and protein expression levels, even in the presence of uncertainty about model parameters.
Date Issued
2017-08-23
Date Acceptance
2017-07-21
Citation
Royal Society Open Science, 2017, 4 (8)
ISSN
2054-5703
Publisher
Royal Society, The
Journal / Book Title
Royal Society Open Science
Volume
4
Issue
8
Copyright Statement
© 2017 The Authors.
Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
License URL
Identifier
PII: rsos160790
Subjects
model invalidation
molecular noise
reachability analysis
stochastic control
synthetic biology
Publication Status
Published online
Article Number
160790