Cohesion: a core outcome set for the treatment of neonatal encephalopathy
File(s)
Author(s)
Type
Journal Article
Abstract
BACKGROUND: Heterogeneity in outcomes reported in trials of interventions for the treatment of neonatal encephalopathy (NE)
makes evaluating the effectiveness of treatments difficult. Developing a core outcome set for NE treatment would enable
researchers to measure and report the same outcomes in future trials. This would minimise waste, ensure relevant outcomes are
measured and enable evidence synthesis. Therefore, we aimed to develop a core outcome set for treating NE.
METHODS: Outcomes identified from a systematic review of the literature and interviews with parents were prioritised by
stakeholders (n = 99 parents/caregivers, n = 101 healthcare providers, and n = 22 researchers/ academics) in online Delphi surveys.
Agreement on the outcomes was achieved at online consensus meetings attended by n = 10 parents, n = 18 healthcare providers,
and n = 13 researchers/ academics.
RESULTS: Seven outcomes were included in the final core outcome set: survival; brain injury on imaging; neurological status at
discharge; cerebral palsy; general cognitive ability; quality of life of the child, and adverse events related to treatment.
CONCLUSION: We developed a core outcome set for the treatment of NE. This will allow future trials to measure and report the
same outcomes and ensure results can be compared. Future work should identify how best to measure the COS.
makes evaluating the effectiveness of treatments difficult. Developing a core outcome set for NE treatment would enable
researchers to measure and report the same outcomes in future trials. This would minimise waste, ensure relevant outcomes are
measured and enable evidence synthesis. Therefore, we aimed to develop a core outcome set for treating NE.
METHODS: Outcomes identified from a systematic review of the literature and interviews with parents were prioritised by
stakeholders (n = 99 parents/caregivers, n = 101 healthcare providers, and n = 22 researchers/ academics) in online Delphi surveys.
Agreement on the outcomes was achieved at online consensus meetings attended by n = 10 parents, n = 18 healthcare providers,
and n = 13 researchers/ academics.
RESULTS: Seven outcomes were included in the final core outcome set: survival; brain injury on imaging; neurological status at
discharge; cerebral palsy; general cognitive ability; quality of life of the child, and adverse events related to treatment.
CONCLUSION: We developed a core outcome set for the treatment of NE. This will allow future trials to measure and report the
same outcomes and ensure results can be compared. Future work should identify how best to measure the COS.
Date Issued
2024-03
Date Acceptance
2023-09-18
Citation
Pediatric Research, 2024, 95 (4), pp.922-930
ISSN
0031-3998
Publisher
Springer Nature
Start Page
922
End Page
930
Journal / Book Title
Pediatric Research
Volume
95
Issue
4
Copyright Statement
© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Identifier
https://www.nature.com/articles/s41390-023-02938-y#citeas
Publication Status
Published
Date Publish Online
2023-12-22