Understanding the genetics of adult-onset dilated cardiomyopathy: what a clinician needs to know.
File(s)
Accepted version
Author(s)
Tayal, Upasana
Ware, James S
Lakdawala, Neal K
Heymans, Stephane
Prasad, Sanjay K
Type
Journal Article
Abstract
There is increasing understanding of the genetic basis to dilated cardiomyopathy and in this review, we offer a practical primer for the practising clinician. We aim to help all clinicians involved in the care of patients with dilated cardiomyopathy to understand the clinical relevance of the genetic basis of dilated cardiomyopathy, introduce key genetic concepts, explain which patients and families may benefit from genetic testing, which genetic tests are commonly performed, how to interpret genetic results, and the clinical applications of results. We conclude by reviewing areas for future research in this dynamic field.
Date Issued
2021-06-21
Date Acceptance
2021-05-19
Citation
European Heart Journal, 2021, 42 (24), pp.2384-2396
ISSN
0195-668X
Publisher
European Society of Cardiology
Start Page
2384
End Page
2396
Journal / Book Title
European Heart Journal
Volume
42
Issue
24
Copyright Statement
© The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model). This is a pre-copy-editing, author-produced version of an article accepted for publication in European Heart Journal following peer review. The definitive publisher-authenticated version Upasana Tayal, James S Ware, Neal K Lakdawala, Stephane Heymans, Sanjay K Prasad, Understanding the genetics of adult-onset dilated cardiomyopathy: what a clinician needs to know, European Heart Journal, Volume 42, Issue 24, 21 June 2021, Pages 2384–2396 is available online at: https://doi.org/10.1093/eurheartj/ehab286
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model). This is a pre-copy-editing, author-produced version of an article accepted for publication in European Heart Journal following peer review. The definitive publisher-authenticated version Upasana Tayal, James S Ware, Neal K Lakdawala, Stephane Heymans, Sanjay K Prasad, Understanding the genetics of adult-onset dilated cardiomyopathy: what a clinician needs to know, European Heart Journal, Volume 42, Issue 24, 21 June 2021, Pages 2384–2396 is available online at: https://doi.org/10.1093/eurheartj/ehab286
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/34153989
PII: 6307392
Subjects
Dilated cardiomyopathy
Genetics
Heart
Adult
Cardiomyopathy, Dilated
Genetic Testing
Humans
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2021-06-21