In the past decade, significant research efforts have been devoted to mineral chemistrystudies to assist porphyry exploration. These activities can be divided into two majorfields of research: (1) porphyry indicator minerals (PIMs), which are used to identify thepresence of, or potential for, porphyry-style mineralization based on the chemistry ofmagmatic minerals such as zircon, plagioclase and apatite, or resistate hydrothermalminerals such as magnetite; and (2) porphyry vectoring and fertility tools (PVFTs),which use the chemical compositions of hydrothermal minerals such as epidote,chlorite and alunite to predict the likely direction and distance to mineralized centers,and the potential metal endowment of a mineral district. This new generation ofexploration tools has been enabled by advances in and increased access to laserablation-inductively coupled plasma mass spectrometry (LA-ICP-MS), short wavelength infrared (SWIR), visible near-infrared (VNIR) and hyperspectral technologies.PIMs and PVFTs show considerable promise for exploration and are starting to beapplied to the diversity of environments that host porphyry and epithermal depositsglobally. Industry has consistently supported development of these tools, in the case ofPVFTs encouraged by several successful blind tests where deposit centers havesuccessfully been predicted from distal propylitic settings. Industry adoption is steadilyincreasing but is restrained by a lack of the necessary analytical equipment andexpertise in commercial laboratories, and also by the on-going reliance on well-established geochemical exploration techniques (e.g., sediment, soil and rock-chipsampling) that have aided the discovery of near-surface resources over many decades, are now proving less effective in the search for deeply buried mineral resources, and for those concealed under cover.