Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure: a cardiac magnetic resonance imaging study
OA Location
Author(s)
Type
Journal Article
Abstract
Background
The pulmonary artery (PA) distends as pressure increases.
Hypothesis
The ratio of PA to aortic (Ao) diameter may be an indicator of pulmonary hypertension and consequently carry prognostic information in patients with chronic heart failure (HF).
Methods
Patients with chronic HF and control subjects undergoing cardiac magnetic resonance imaging were evaluated. The main PA diameter and the transverse axial Ao diameter at the level of bifurcation of the main PA were measured. The maximum diameter of both vessels was measured throughout the cardiac cycle and the PA/Ao ratio was calculated.
Results
A total of 384 patients (mean age, 69 years; mean left ventricular ejection fraction, 40%; median NT‐proBNP, 1010 ng/L [interquartile range, 448–2262 ng/L]) and 38 controls were included. Controls and patients with chronic HF had similar maximum Ao and PA diameters and PA/Ao ratio. During a median follow‐up of 1759 days (interquartile range, 998–2269 days), 181 patients with HF were hospitalized for HF or died. Neither PA diameter nor PA/Ao ratio predicted outcome in univariable analysis. In a multivariable model, only age and NT‐proBNP were independent predictors of adverse events.
Conclusions
The PA/Ao ratio is not a useful method to stratify prognosis in patients with HF.
The pulmonary artery (PA) distends as pressure increases.
Hypothesis
The ratio of PA to aortic (Ao) diameter may be an indicator of pulmonary hypertension and consequently carry prognostic information in patients with chronic heart failure (HF).
Methods
Patients with chronic HF and control subjects undergoing cardiac magnetic resonance imaging were evaluated. The main PA diameter and the transverse axial Ao diameter at the level of bifurcation of the main PA were measured. The maximum diameter of both vessels was measured throughout the cardiac cycle and the PA/Ao ratio was calculated.
Results
A total of 384 patients (mean age, 69 years; mean left ventricular ejection fraction, 40%; median NT‐proBNP, 1010 ng/L [interquartile range, 448–2262 ng/L]) and 38 controls were included. Controls and patients with chronic HF had similar maximum Ao and PA diameters and PA/Ao ratio. During a median follow‐up of 1759 days (interquartile range, 998–2269 days), 181 patients with HF were hospitalized for HF or died. Neither PA diameter nor PA/Ao ratio predicted outcome in univariable analysis. In a multivariable model, only age and NT‐proBNP were independent predictors of adverse events.
Conclusions
The PA/Ao ratio is not a useful method to stratify prognosis in patients with HF.
Date Issued
2018-01-01
Date Acceptance
2017-10-19
Citation
Clinical Cardiology, 2018, 41 (1), pp.20-27
ISSN
0160-9289
Publisher
Wiley
Start Page
20
End Page
27
Journal / Book Title
Clinical Cardiology
Volume
41
Issue
1
Copyright Statement
© 2018 Wiley Periodicals, Inc.
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Aortic Diameter
Cardiac MRI
Heart Failure
PA/Ao Ratio
Prognosis
Pulmonary Artery
PRESERVED EJECTION FRACTION
COMPUTED-TOMOGRAPHY
HYPERTENSION
DISEASE
EXACERBATIONS
ENLARGEMENT
ULTRASOUND
PRESSURES
COMMUNITY
DIAGNOSIS
Publication Status
Published
Date Publish Online
2018-01-23