Transient imine directing groups for the C–H functionalisation of aldehydes, ketones and amines: an update 2018-2020
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Published version
Author(s)
Higham, Joe
Bull, James A
Type
Journal Article
Abstract
The use of pre-installed directing groups has become a popular and powerful strategy to control site selectivity in transition metal catalysed C–H functionalisation reactions. However, the necessity for directing group installation and removal reduces the efficiency of a directed C–H functionalisation method. To overcome this limitation, taking inspiration from organocatalytic methodologies, the use of transient directing groups has arisen. These methods allow for a transient ligand to be used, potentially in catalytic quantities, without the need for discrete installation or removal steps, enabling the discovery of more efficient, and mechanistically intriguing, dual catalytic methods. This review summarises recent developments in this fast moving field covering >70 new methodologies, highlighting new directing group designs and advances in mechanistic understanding. It covers progress since 2018, providing an update to our previous review of the field.
Date Issued
2020-09-08
Date Acceptance
2020-09-08
Citation
Organic and Biomolecular Chemistry, 2020, 18 (37), pp.7291-7315
ISSN
1477-0520
Publisher
Royal Society of Chemistry
Start Page
7291
End Page
7315
Journal / Book Title
Organic and Biomolecular Chemistry
Volume
18
Issue
37
Copyright Statement
© The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence http://creativecommons.org/licenses/by/3.0/.
License URL
Sponsor
The Royal Society
The Royal Society
The Royal Society
Identifier
https://pubs.rsc.org/en/content/articlelanding/2020/OB/D0OB01587C#!divAbstract
Grant Number
UF140161
RG150444
RGF\EA\180031
Subjects
Organic Chemistry
0304 Medicinal and Biomolecular Chemistry
0305 Organic Chemistry
Publication Status
Published
Date Publish Online
2020-09-08