The respiratory microbiome is linked to the severity of RSV infections and the persistence of symptoms in children
Author(s)
Kristensen, Maartje
Piters, Wouter AA de Steenhuijsen
Wildenbeest, Joanne
van Houten, Marlies A
Zuurbier, Roy P
Type
Journal Article
Abstract
Respiratory syncytial virus (RSV) is the leading cause of infant respiratory infections and hospitalizations. To investigate the relationship between the respiratory microbiome and RSV infection, we sequence nasopharyngeal samples from a birth cohort and a pediatric case-control study (Respiratory Syncytial virus Consortium in Europe [RESCEU]). 1,537 samples are collected shortly after birth (“baseline”), during RSV infection and convalescence, and from healthy controls. We find a modest association between baseline microbiota and the severity of consecutive RSV infections. The respiratory microbiota during infection clearly differs between infants with RSV and controls. Haemophilus, Streptococcus, and Moraxella abundance are associated with severe disease and persistence of symptoms, whereas stepwise increasing abundance of Dolosigranulum and Corynebacterium is associated with milder disease and health. We conclude that the neonatal respiratory microbiota is only modestly associated with RSV severity during the first year of life. However, the respiratory microbiota at the time of infection is strongly associated with disease severity and residual symptoms.
Date Issued
2024-12-17
Date Acceptance
2024-11-04
Citation
Cell Reports Medicine, 2024, 5 (12)
ISSN
2666-3791
Publisher
Elsevier
Journal / Book Title
Cell Reports Medicine
Volume
5
Issue
12
Copyright Statement
© 2024 The Authors. Published by Elsevier Inc. This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39642873
PII: S2666-3791(24)00607-4
Subjects
BACTERIAL COINFECTION
Cell Biology
COLONIZATION
DISEASE
Life Sciences & Biomedicine
Medicine, Research & Experimental
MORBIDITY
MORTALITY
NASOPHARYNGEAL MICROBIOTA
PNEUMONIA
Research & Experimental Medicine
RISK
Science & Technology
SYNCYTIAL VIRUS-INFECTION
YOUNG-CHILDREN
Publication Status
Published
Coverage Spatial
United States
Article Number
101836
Date Publish Online
2024-12-05