The papers in this special issue present a selection of high quality research papers on wearable and flexible integrated sensors for screening, diagnostics, and treatment. Emerging flexible and wearable physical sensing devices create huge potential for many vital healthcare and biomedical applications including artificial electronic skins, physiological monitoring and assessment systems, therapeutic and drug delivery platforms, etc. Monitoring of vital physiological parameters in hospital and/or home environments has been of tremendous interests to healthcare practitioners for a long time. Robust and reliable sensors with excellent flexibility and stretchability are essential in the development of pervasive health monitoring systems with the capability of continuously tracking physiological signals of human body without conspicuous discomfort and invasiveness.