The effect of acute non-invasive ventilation on corticospinal pathways to the respiratory muscles in chronic obstructive pulmonary disease
Author(s)
Type
Journal Article
Abstract
Chronic obstructive pulmonary disease is associated with altered cortical excitability. The relevance of this to the need for non-invasive ventilation is not known. We assessed the diaphragm response to transcranial magnetic stimulation in terms of motor threshold and latency as well as assessing intracortical excitability using paired stimulation in eight long-term users and six non-users of home ventilation with COPD. Overall, intracortical facilitation was strongly correlated with inspiratory muscle strength (r2 0.72, p < 0.001) whereas intracortical inhibition was correlated with PaCO2 (r2 0.51, p = 0.01). The two groups did not differ in motor evoked potential or latency, nor in the excitability of intracortical inhibitory or facilitatory circuits assessed using paired stimulation. The acute effect of isocapnic non-invasive ventilation was studied in six established ventilator users. Diaphragm motor evoked potential fell but there was no effect on intracortical facilitation or inhibition, implying an effect of neuromechanical feedback at brainstem or spinal level.
Date Issued
2012-07-31
Date Acceptance
2012-05-18
Citation
Respiratory Physiology and Neurobiology, 2012, 183 (1), pp.41-47
ISSN
1569-9048
Publisher
Elsevier
Start Page
41
End Page
47
Journal / Book Title
Respiratory Physiology and Neurobiology
Volume
183
Issue
1
Copyright Statement
© 2012 Elsevier B.V. Open access under CC BY license http://creativecommons.org/licenses/by/3.0/.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000306980900007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Physiology
Respiratory System
Transcranial magnetic stimulation
Diaphragm
Motor cortex
Paired stimulation
TRANSCRANIAL MAGNETIC STIMULATION
INSPIRATORY PRESSURE
HUMAN DIAPHRAGM
INTRACORTICAL INHIBITION
LOAD COMPENSATION
VOLUNTARY DRIVE
MOTOR CONTROL
NEURAL DRIVE
INHALED CO2
FACILITATION
Publication Status
Published
Date Publish Online
2012-05-28