Novel virus-mimicking polymer-functionalised lipid nanoparticles for enhanced intracellular RNA delivery and stable storage at ambient temperatures
File(s)
Author(s)
Bhamra, Apanpreet Kaur
Type
Thesis
Abstract
Research into vaccines and biotherapeutics based on nucleic acids is the most promising to address major diseases and illnesses, particularly cancers and viruses. RNA-based vaccines are advantageous due to their simple manufacturing process, addressing the issue of immunising against new variants efficiently. However, this comes with significant challenges.
Version
Open Access
Date Issued
2022-02-01
Date Awarded
2022-04-01
Copyright Statement
Creative Commons Attribution NonCommercial Licence
License URL
Advisor
Chen, Rongjun
Sponsor
Engineering and Physical Sciences Research Council
Publisher Department
Chemical Engineering
Publisher Institution
Imperial College London
Qualification Level
Doctoral
Qualification Name
Doctor of Philosophy (PhD)