Domain movements of the enhancer-dependent sigma factor drive DNA delivery into the RNA polymerase active site: insights from single molecule studies

Sharma, A; Leach, RN; Gell, C; Zhang, N; Burrows, PC; Shepherd, DA; Wigneshweraraj, S; Smith, DA; Zhang, X; Buck, M; Stockley, PG; Tuma, R

doi:https://dx.doi.org/10.1093/nar/gku146

File(s)

Domain movements of the enhancer-dependent sigma factor drive DNA delivery into the RNA polymerase active site: insights from single molecule studies.pdf (13.13 MB)

Published version

Author(s)

Sharma, A

Leach, RN

Gell, C

Zhang, N

Burrows, PC

more

Type

Journal Article

Date Issued

2014-04-01

URI

http://hdl.handle.net/10044/1/53577

DOI

https://dx.doi.org/10.1093/nar/gku146

ISSN

0305-1048

Publisher

OXFORD UNIV PRESS

Start Page

5177

End Page

5190

Journal / Book Title

NUCLEIC ACIDS RESEARCH

Volume

42

Issue

8

Copyright Statement

The Author(s) 2014. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which
permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Sponsor

Biotechnology and Biological Sciences Research Council (BBSRC)

Identifier

http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336092300044&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Grant Number

BB/E000975/1

BB/G001278/1

BB/H012249/1

BB/J002828/1

BB/K000233/1

Subjects

Science & Technology

Life Sciences & Biomedicine

Biochemistry & Molecular Biology

BIOCHEMISTRY & MOLECULAR BIOLOGY

ALTERNATING-LASER EXCITATION

TRANSCRIPTION INITIATION

PROMOTER DNA

STRUCTURAL BASIS

BINDING

HOLOENZYME

ACTIVATION

MECHANISM

PROTEIN

FLUORESCENCE

Catalytic Domain

DNA

DNA-Directed RNA Polymerases

Fluorescent Dyes

Nucleotides

Promoter Regions, Genetic

Protein Structure, Tertiary

RNA Polymerase Sigma 54

Templates, Genetic

Transcription, Genetic

05 Environmental Sciences

06 Biological Sciences

08 Information And Computing Sciences

Developmental Biology

Publication Status

Published