A diffusion-activation model of CaMKII translocation waves in dendrites
File(s)
Accepted version
Author(s)
Earnshaw, Berton A
Bressloff, Paul C
Type
Journal Article
Abstract
Ca2+-calmodulin-dependent protein kinase II (CaMKII) is a key regulator of glutamatergic synapses and plays an essential role in many forms of synaptic plasticity. It has recently been observed that stimulating dendrites locally with a single glutamate/glycine puff induces a local translocation of CaMKII into spines that subsequently spreads in a wave-like manner towards the distal dendritic arbor. Here we present a mathematical model of the diffusion, activation and translocation of dendritic CaMKII. We show how the nonlinear dynamics of CaMKII diffusion-activation generates a propagating translocation wave, provided that the rate of activation is sufficiently fast. We also derive an explicit formula for the wave speed as a function of physiological parameters such as the diffusivity of CaMKII and the density of spines. Our model provides a quantitative framework for understanding the spread of CaMKII translocation and its possible role in heterosynaptic plasticity.
Date Issued
2010-02
Date Acceptance
2009-09-16
Citation
Journal of Computational Neuroscience, 2010, 28 (1), pp.77-89
ISSN
0929-5313
Publisher
Springer
Start Page
77
End Page
89
Journal / Book Title
Journal of Computational Neuroscience
Volume
28
Issue
1
Copyright Statement
Copyright © 2010 Springer-Verlag. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10827-009-0188-9
Identifier
http://dx.doi.org/10.1007/s10827-009-0188-9
Publication Status
Published
Date Publish Online
2009-11-05