Multifunctional hyaluronate - nanoparticle hybrid systems for diagnostic, therapeutic and theranostic applications
File(s)
Accepted version
Author(s)
Kim, Hyemin
Park, Yoonsang
Stevens, Molly M
Kwon, Woosung
Hahn, Sei Kwang
Type
Journal Article
Abstract
Diagnostic and therapeutic nanoparticles have been actively investigated for the last few decades as new platforms for biomedical applications. Despite their great versatility and potency, nanoparticles have generally required further modification with biocompatible materials such as biopolymers and synthetic polymers for in vivo administration to improve their biological functions, stability, and biocompatibility. Among a variety of natural and synthetic biomaterials, hyaluronate (HA) has been considered a promising biomolecule with which to construct nanohybrid systems, as it can enable long-term and efficient delivery of nanoparticles to target sites as well as physiological stabilization of nanoparticles by forming hydrophilic shells. In this review, we first describe various kinds of HA derivatives and their interactions with nanoparticles, and discuss how to design and develop optimal HA-nanoparticle hybrid systems for biomedical applications. Furthermore, we show several exemplary applications of HA-nanoparticle hybrid systems and provide our perspectives to their futuristic translational applications.
Date Issued
2019-06-10
Date Acceptance
2019-04-03
Citation
Journal of Controlled Release, 2019, 303, pp.55-66
ISSN
0168-3659
Publisher
Elsevier
Start Page
55
End Page
66
Journal / Book Title
Journal of Controlled Release
Volume
303
Copyright Statement
© 2019 Elsevier B.V. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30954619
PII: S0168-3659(19)30195-6
Subjects
Conjugate
Diagnosis
Drug delivery.
Hyaluronate
Nanoparticle
Publication Status
Published
Coverage Spatial
Netherlands
Date Publish Online
2019-04-05