Insulin sensitivity assessed using urine C peptide creatinine ratio (UCPCR) in pregnancy: cross-sectional analysis of an English multiethnic cohort
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Published version
Author(s)
Mendoza Mathison, LC
Markosca, Ankica
Valaiyapathi, Rajalaskmi
Thorn, Chloe
Dornhorst, Anne
Type
Journal Article
Abstract
To assess urinary C peptide creatinine ratio (UCPCR)
used in a modified Matsuda equation to measure insulin
sensitivity (IS) in pregnancy.
research and design methods
In this cross-sectional
study, two IS measurements were calculated in 73
pregnant women at ~28 weeks of gestation by two
separate methods using modified Matsuda equations.
The first using the 0 and 120
min serum C peptide
concentration during a 75
g oral glucose tolerance test
(OGTT) and the second using the 0 and 120
min UCPCR
values. The calculated IS measurements from the two
methodologies were evaluated using Person’s test and
linear regression analysis. The relationship between IS
OGTT
UCPCR and the fasting second void UCPCR and 120
min
UCPCR was assessed using Pearson correlation and linear
regression analysis after logarithmic transformation of the
variables. Statistical analysis was performed using SPSS
V.22.
results
The IS measured using serum C peptide (IS
OGTTc-
pep
) in the modified Matsuda equation correlated with the
IS measurement using serum UCPCR (IS
OGTT-UCPCR
) (r 0.704,
p<0.0001). A strong correlation was found between the
IS
OGTT-UCPCR
and the fasting UCPCR (r −0.916, p<0.0001),
displaying a hyperbolic relationship.
Conclusion
The UCPCR provides a practical methodology
to assess IS and
β
-cell function in pregnancy
used in a modified Matsuda equation to measure insulin
sensitivity (IS) in pregnancy.
research and design methods
In this cross-sectional
study, two IS measurements were calculated in 73
pregnant women at ~28 weeks of gestation by two
separate methods using modified Matsuda equations.
The first using the 0 and 120
min serum C peptide
concentration during a 75
g oral glucose tolerance test
(OGTT) and the second using the 0 and 120
min UCPCR
values. The calculated IS measurements from the two
methodologies were evaluated using Person’s test and
linear regression analysis. The relationship between IS
OGTT
UCPCR and the fasting second void UCPCR and 120
min
UCPCR was assessed using Pearson correlation and linear
regression analysis after logarithmic transformation of the
variables. Statistical analysis was performed using SPSS
V.22.
results
The IS measured using serum C peptide (IS
OGTTc-
pep
) in the modified Matsuda equation correlated with the
IS measurement using serum UCPCR (IS
OGTT-UCPCR
) (r 0.704,
p<0.0001). A strong correlation was found between the
IS
OGTT-UCPCR
and the fasting UCPCR (r −0.916, p<0.0001),
displaying a hyperbolic relationship.
Conclusion
The UCPCR provides a practical methodology
to assess IS and
β
-cell function in pregnancy
Date Issued
2018-05-03
Date Acceptance
2018-03-06
Citation
BMJ Open
ISSN
2044-6055
Publisher
BMJ Journals
Journal / Book Title
BMJ Open
Volume
8
Copyright Statement
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Subjects
diabetes In pregnancy
maternal medicine
physiology
Publication Status
Accepted
Article Number
e020029
Date Publish Online
2018-05-03