HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis.
File(s)
Author(s)
Type
Journal Article
Abstract
We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.
Date Issued
2020-09-21
Date Acceptance
2020-07-23
Citation
Antimicrobial Agents and Chemotherapy, 2020, 64 (10), pp.1-7
ISSN
0066-4804
Publisher
American Society for Microbiology
Start Page
1
End Page
7
Journal / Book Title
Antimicrobial Agents and Chemotherapy
Volume
64
Issue
10
Copyright Statement
© 2020 Loiseau et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/).
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/).
License URL
Sponsor
Wellcome Trust
Wellcome Trust
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32718966
PII: AAC.00782-20
Grant Number
104803/Z/14/Z
WDAI_P83556
Subjects
0605 Microbiology
1108 Medical Microbiology
1115 Pharmacology and Pharmaceutical Sciences
Microbiology
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2020-09-21