A framework for the design, modeling and optimization of biomedical systems
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
We present an overview of the key building blocks of a design framework for modeling and optimization of biomedical systems with main focus on leukemia, that we have been developing in the Biological Systems Engineering Laboratory and the Centre for Process Systems Engineering at Imperial College. The framework features the following areas: (i) a three-dimensional, biomimetic, in vitro platform for culturing both healthy and diseased blood; (ii) a novel, hollow fiber bioreactor that upgrades this in vitro platform to enable expansion and continuous harvesting of healthy and diseased blood; (iii) a global optimization-based approach for the design and operation of the aforementioned bioreactor; (iv) a pharmacokinetic / pharmacodynamic model representing patient response to Acute Myeloid Leukemia treatment; (v) an experimental framework for cell cycle modeling and quantitative analysis of environmental stress. This manuscript recapitulates the progress made in the different areas as well as the way in which these areas are connected, finally leading to a hybrid in vitro/in silico platform which allows the optimization of the ex vivo expansion of healthy and diseased blood.
Date Issued
2014-07-17
Citation
2014
ISSN
1570-7946
Publisher
Elsevier
Start Page
225
End Page
236
Journal / Book Title
Computer Aided Chemical Engineering
Volume
34
Copyright Statement
© 2014 Elsevier B.V. All rights reserved. NOTICE: this is the author’s version of a work that was accepted for publication in Computer Aided Chemical Engineering. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in COMPUTER-AIDED CHEMICAL ENGINEERING, Vol.: 34, (2014) DOI: 10.1016/B978-0-444-63433-7.50023-7
Description
27.11.14 KB OK to add accepted version to spiral, subject to12 month embargo
Identifier
B9780444634337.500237
Publication Status
Published
Coverage Spatial
Washington, USA