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Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose
File(s)
1418.full.pdf (356.41 KB)
Published version
OA Location
Author(s)
Reynolds, Catherine J
Pade, Corinna
Gibbons, Joseph M
Butler, David K
Otter, Ashley D
Type
Journal Article
Abstract
SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern. We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in healthcare workers (HCW) followed longitudinally, with or without prior Wuhan-Hu-1 SARS-CoV-2 infection. After one dose, individuals with prior infection showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351. By comparison, HCW receiving one vaccine dose without prior infection showed reduced immunity against variants. B.1.1.7 and B.1.351 spike mutations resulted in increased, abrogated or unchanged T cell responses depending on human leukocyte antigen (HLA) polymorphisms. Single dose vaccination with BNT162b2 in the context of prior infection with a heterologous variant substantially enhances neutralizing antibody responses against variants.
Date Issued
2021-06-25
Date Acceptance
2021-04-26
Citation
Science, 2021, 372 (6549), pp.1418-1423
URI
DOI
ISSN
0036-8075
Publisher
American Association for the Advancement of Science
Start Page
1418
End Page
1423
Journal / Book Title
Science
Volume
372
Issue
6549
Copyright Statement
© 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
Medical Research Council (MRC)
Medical Research Council (MRC)
UKRI
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33931567
PII: science.abh1282
Grant Number
MR/V036939/1
MR/S019553/1
UOB162663
Subjects
UK COVIDsortium Immune Correlates Network
UK COVIDsortium Investigators
General Science & Technology
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2021-04-30