Neurocognitive and functional impairment in adult and paediatric tuberculous meningitis [version 1; peer review: 2 approved]

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OA Location

https://d212y8ha88k086.cloudfront.net/manuscripts/16984/700e948b-7ccd-474b-abab-094455a29d5f_15516_-_angharad_davis.pdf?doi=10.12688/wellcomeopenres.15516.1&numberOfBrowsableCollections=4&numberOfBrowsableInstitutionalCollections=0&numberOfBrowsableGateways=12

Author(s)

Davis, Angharad

Nightingale, Sam

Springer, Priscilla

Solomons, Regan

Arenivas, Ana

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Type

Journal Article

Abstract

In those who survive tuberculous meningitis (TBM), the long-term outcome is uncertain; individuals may suffer neurocognitive, functional and psychiatric impairment, which may significantly affect their ability to lead their lives as they did prior to their diagnosis of TBM. In children who survive, severe illness has occurred at a crucial timepoint in their development, which can lead to behavioural and cognitive delay. The extent and nature of this impairment is poorly understood, particularly in adults. This is in part due to a lack of observational studies in this area but also inconsistent inclusion of outcome measures which can quantify these deficits in clinical studies. This leads to a paucity of appropriate rehabilitative therapies available for these individuals and their caregivers, as well as burden at a socioeconomic level. In this review, we discuss what is known about neurocognitive impairment in TBM, draw on lessons learnt from other neurological infections and discuss currently available and emerging tools to evaluate function and cognition and their value in TBM. We make recommendations on which measures should be used at what timepoints to assess for impairment, with a view to optimising and standardising assessment of neurocognitive and functional impairment in TBM research.

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Date Issued

2019-11-13

Date Acceptance

2019-11-01

Citation

Wellcome Open Research, 2019, 4 (178)

URI

http://hdl.handle.net/10044/1/76993

URL

https://wellcomeopenresearch.org/articles/4-178/v1

DOI

https://www.dx.doi.org/10.12688/wellcomeopenres.15516.1

ISSN

2398-502X

Publisher

F1000Research

Journal / Book Title

Wellcome Open Research

Volume

4

Issue

178

Copyright Statement

© 2019 Davis AG et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

License URL

http://creativecommons.org/licenses/by/4.0/

Identifier

https://wellcomeopenresearch.org/articles/4-178/v1

Subjects

Tuberculous Meningitis International Research Consortium

Publication Status

Published

Date Publish Online

2019-11-13