The Consortium on Vulnerability to Externalising Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India
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Accepted version
Supplementary information
Author(s)
Zhang, Yuning
Elliott, Paul
Toledano, Mireille
Schumann, Gunter
Type
Journal Article
Abstract
The global burden of disease attributable to externalising disorders such as alcohol misuse
calls urgently for effective prevention and intervention. As our current knowledge is mainly
derived from high-income countries such in Europe and North-America, it is difficult to
address the wider socio-cultural, psychosocial context, and genetic factors in which risk and
resilience are embedded in low- and medium-income countries. c-VEDA was established as
the first and largest India-based multi-site cohort investigating the vulnerabilities for the
development of externalising disorders, addictions, and other mental health problems. Using
a harmonised data collection plan coordinated with multiple cohorts in China, USA, and
Europe, baseline data were collected from 7 study sites between November 2016 and May
2019. 9010 participants between the ages of 6 and 23 were assessed during this time, amongst
which 1278 participants underwent more intensive assessments including MRI scans. Both
waves of follow-ups have started according to the accelerated cohort structure with planned
missingness design. Here we present descriptive statistics on several key domains of
assessments, and the full baseline dataset will be made accessible for researchers outside the
consortium in September 2019. More details can be found on our website [cveda.org].
calls urgently for effective prevention and intervention. As our current knowledge is mainly
derived from high-income countries such in Europe and North-America, it is difficult to
address the wider socio-cultural, psychosocial context, and genetic factors in which risk and
resilience are embedded in low- and medium-income countries. c-VEDA was established as
the first and largest India-based multi-site cohort investigating the vulnerabilities for the
development of externalising disorders, addictions, and other mental health problems. Using
a harmonised data collection plan coordinated with multiple cohorts in China, USA, and
Europe, baseline data were collected from 7 study sites between November 2016 and May
2019. 9010 participants between the ages of 6 and 23 were assessed during this time, amongst
which 1278 participants underwent more intensive assessments including MRI scans. Both
waves of follow-ups have started according to the accelerated cohort structure with planned
missingness design. Here we present descriptive statistics on several key domains of
assessments, and the full baseline dataset will be made accessible for researchers outside the
consortium in September 2019. More details can be found on our website [cveda.org].
Date Issued
2020-08-01
Date Acceptance
2020-01-17
Citation
Molecular Psychiatry, 2020, 25, pp.1618-1630
ISSN
1359-4184
Publisher
Springer Nature [academic journals on nature.com]
Start Page
1618
End Page
1630
Journal / Book Title
Molecular Psychiatry
Volume
25
Copyright Statement
© Springer Nature Limited 2020
Sponsor
Medical Research Council (MRC)
Medical Research Council (MRC)
Grant Number
MR/L01341X/1
RTJ964197401
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Neurosciences
Psychiatry
Neurosciences & Neurology
IMAGING GENETICS
PSYCHOSOCIAL STRESS
BRAIN-FUNCTION
MISSING DATA
REINFORCEMENT
IMAGEN
c-VEDA consortium
Psychiatry
06 Biological Sciences
11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
Publication Status
Published
Date Publish Online
2020-03-12