Optical glucose sensors based on hexagonally-packed 2.5-dimensional photonic concavities imprinted in phenylboronic acid functionalized hydrogel films
Author(s)
Bajgrowicz-Cieslak, Magdalena
Alqurashi, Yousef
Elshereif, Mohamed Ismail
Yetisen, Ali K
Hassan, Muhammad Umair
Type
Journal Article
Abstract
Continuous glucose monitoring aims to achieve accurate control of blood glucose concentration to prevent hypo/hyperglycaemia in diabetic patients. Hydrogel-based systems have emerged as a reusable sensing platform to quantify biomarkers in high-risk patients at clinical and point-of-care settings. The capability to integrate hydrogel-based systems with optical transducers will provide quantitative and colorimetric measurements via spectrophotometric analyses of biomarkers. Here, we created an imprinting method to rapidly produce 2.5D photonic concavities in phenylboronic acid functionalized hydrogel films. Our method exploited diffraction properties of hexagonally-packed 2.5D photonic microscale concavities having a lattice spacing of 3.3 μm. Illumination of the 2.5D hexagonally-packed structure with a monochromatic light source in transmission mode allowed reversible and quantitative measurements of variation in the glucose concentration based on first order lattice interspace tracking. Reversible covalent phenylboronic acid coupling with cis-diols of glucose molecules expanded the hydrogel matrix by ∼2% and 34% in the presence of glucose concentrations of 1 mM and 200 mM, respectively. A Donnan osmotic pressure induced volumetric expansion of the hydrogel matrix due to increasing glucose concentrations (1–200 mM), resulted in a nanoscale modulation of the lattice interspace, and shifted the diffraction angle (∼45° to 36°) as well as the interspacing between the 1st order diffraction spots (∼8 to 3 mm). The sensor exhibited a maximum lattice spacing diffraction shift within a response time of 15 min in a reversible manner. The developed 2.5D photonic sensors may have application in medical point-of-care diagnostics, implantable chips, and wearable continuous glucose monitoring devices.
Date Issued
2017-11-23
Date Acceptance
2017-11-16
Citation
RSC Advances: an international journal to further the chemical sciences, 2017, 7 (85), pp.53916-53924
ISSN
2046-2069
Publisher
Royal Society of Chemistry
Start Page
53916
End Page
53924
Journal / Book Title
RSC Advances: an international journal to further the chemical sciences
Volume
7
Issue
85
Copyright Statement
Open Access Article. Published on 23 November 2017. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000416831000031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
RESPONSIVE HYDROGELS
HOLOGRAPHIC SENSORS
DIABETES-MELLITUS
BORONIC ACIDS
PREVALENCE
NANOSTRUCTURES
TYPE-1
TRENDS
Publication Status
Published