Sirtuin-1: a new potential therapeutic target for rhinosinusitis? Who 'nose'?
File(s)
Author(s)
Baker, Jonathan R
Type
Journal Article
Abstract
Chronic rhinosinusitis is one of the most common upper respiratory tract diseases. In
the USA chronic rhinosinusitis has a high prevalence, with around 12% of the
population having the disease, and therefore as a consequence the disease has a
high health cost burden (1). Chronic rhinosinusitis is classified as an inflammatory
nasal disease in which the nasal cavities become inflamed and swollen. The disease
can be divided into two distinct disease phenotypes: Chronic rhinosinusitis without
nasal polyps (CRSsNP) and Chronic rhinosinusitis with nasal polyps
(CRSwNP) (2).
One of the major clinical differences between the two subsets of disease is that
CRSwNP patients form nasal polyps within their nasal cavities, with these being
described as inflammatory lesions of sinonasal tissue which further narrow this
space (3). This leads to symptoms of nasal congestion, rhinorrhoea and facial
pressure or pain that is of duration of 12 weeks or longer (3). CRSwNP is believed to
be a disease of eosinophilia, with an impaired sinonasal epithelial barrier that causes
hypersensitivity to inhaled pathogens and particulates, as well as increased
permeability, exacerbating the recruitment of inflammatory cells in response to the
stimulus.
the USA chronic rhinosinusitis has a high prevalence, with around 12% of the
population having the disease, and therefore as a consequence the disease has a
high health cost burden (1). Chronic rhinosinusitis is classified as an inflammatory
nasal disease in which the nasal cavities become inflamed and swollen. The disease
can be divided into two distinct disease phenotypes: Chronic rhinosinusitis without
nasal polyps (CRSsNP) and Chronic rhinosinusitis with nasal polyps
(CRSwNP) (2).
One of the major clinical differences between the two subsets of disease is that
CRSwNP patients form nasal polyps within their nasal cavities, with these being
described as inflammatory lesions of sinonasal tissue which further narrow this
space (3). This leads to symptoms of nasal congestion, rhinorrhoea and facial
pressure or pain that is of duration of 12 weeks or longer (3). CRSwNP is believed to
be a disease of eosinophilia, with an impaired sinonasal epithelial barrier that causes
hypersensitivity to inhaled pathogens and particulates, as well as increased
permeability, exacerbating the recruitment of inflammatory cells in response to the
stimulus.
Date Issued
2018-10-01
Date Acceptance
2018-07-10
Citation
American Journal of Respiratory Cell and Molecular Biology, 2018, 59 (4), pp.412-414
ISSN
1044-1549
Publisher
American Thoracic Society
Start Page
412
End Page
414
Journal / Book Title
American Journal of Respiratory Cell and Molecular Biology
Volume
59
Issue
4
Copyright Statement
© 2018 by the American Thoracic Society.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29995434
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
Respiratory System
NF-KAPPA-B
NASAL POLYPS
INFLAMMATION
EXPRESSION
Epithelial Cells
Humans
Matrix Metalloproteinase 9
Nose
Poly I-C
Rhinitis
Sirtuin 1
Nose
Epithelial Cells
Humans
Rhinitis
Poly I-C
Matrix Metalloproteinase 9
Sirtuin 1
Respiratory System
1102 Cardiorespiratory Medicine and Haematology
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2018-07-11