Preparedness needs research: How fundamental science and international collaboration accelerated the response to COVID-19.
File(s)ppat.1008902.pdf (1.55 MB)
Published version
Author(s)
Kinsella, Cormac M
Santos, Pauline Dianne
Postigo-Hidalgo, Ignacio
Folgueiras-González, Alba
Passchier, Tim Casper
Type
Journal Article
Abstract
The first cluster of patients suffering from coronavirus disease 2019 (COVID-19) was identified on December 21, 2019, and as of July 29, 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been linked with 664,333 deaths and number at least 16,932,996 worldwide. Unprecedented in global societal impact, the COVID-19 pandemic has tested local, national, and international preparedness for viral outbreaks to the limits. Just as it will be vital to identify missed opportunities and improve contingency planning for future outbreaks, we must also highlight key successes and build on them. Concomitant to the emergence of a novel viral disease, there is a 'research and development gap' that poses a threat to the overall pace and quality of outbreak response during its most crucial early phase. Here, we outline key components of an adequate research response to novel viral outbreaks using the example of SARS-CoV-2. We highlight the exceptional recent progress made in fundamental science, resulting in the fastest scientific response to a major infectious disease outbreak or pandemic. We underline the vital role of the international research community, from the implementation of diagnostics and contact tracing procedures to the collective search for vaccines and antiviral therapies, sustained by unique information sharing efforts.
Date Issued
2020-10
Date Acceptance
2020-10-01
Citation
PLoS Pathogens, 2020, 16 (10), pp.1-12
ISSN
1553-7366
Publisher
Public Library of Science (PLoS)
Start Page
1
End Page
12
Journal / Book Title
PLoS Pathogens
Volume
16
Issue
10
Copyright Statement
© 2020 Kinsella et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33035262
PII: PPATHOGENS-D-20-01059
Subjects
Betacoronavirus
Biomedical Research
COVID-19
Contact Tracing
Coronavirus Infections
Humans
International Cooperation
Pandemics
Pneumonia, Viral
SARS-CoV-2
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2020-10-09