The connection between the geological record and dynamic topography driven by mantle convective flow has been established over widely varying temporal and spatial scales. As observations of the process have increased and numerical modeling of thermochemical convection has improved, a burgeoning direction of research targeting outstanding issues in ice age paleoclimate has emerged. This review focuses on studies of the Plio-Pleistocene ice age, including investigations of the stability of ice sheets during ice age warm periods and the inception of Northern Hemisphere glaciation. However, studies that have revealed nuanced connections of dynamic topography to biodiversity, ecology, ocean chemistry, and circulation since the start of the current ice-house world are also considered. In some cases, a recognition of the importance of dynamic topography resolves enigmatic events and in others it confounds already complex, unanswered questions. All such studies highlight the role of solid Earth geophysics in paleoclimate research and undermine a common assumption, beyond the field of glacial isostatic adjustment, that the solid Earth remains a rigid, passive substrate during the evolution of the ice age climate system.