SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition.
File(s)
Author(s)
Altmann, Daniel M
Reynolds, Catherine J
Boyton, Rosemary J
Type
Journal Article
Abstract
COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.
Date Issued
2021-05-18
Date Acceptance
2021-05-01
Citation
Cell Reports Medicine, 2021, 2 (5), pp.1-3
URI
URL
DOI
ISSN
2666-3791
Publisher
Elsevier
Start Page
1
End Page
3
Journal / Book Title
Cell Reports Medicine
Volume
2
Issue
5
Copyright Statement
© 2021. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
License URL
Sponsor
Medical Research Council (MRC)
Medical Research Council (MRC)
UKRI
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/34027499
PII: S2666-3791(21)00114-2
Grant Number
MR/S019553/1
MR/V036939/1
UOB162663
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2021-05-18