The Type 2 Diabetes Knowledge Portal: an open access genetic resource dedicated to type 2 diabetes and related traits
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories of these data seek to be disease-agnostic and therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) is a public resource of genetic datasets and genomic annotations dedicated to type 2 diabetes (T2D) and related traits. Here, we seek to make the T2DKP more accessible to prospective users and more useful to existing users. First, we evaluate the T2DKP's comprehensiveness by comparing its datasets with those of other repositories. Second, we describe how researchers unfamiliar with human genetic data can begin using and correctly interpreting them via the T2DKP. Third, we describe how existing users can extend their current workflows to use the full suite of tools offered by the T2DKP. We finally discuss the lessons offered by the T2DKP toward the goal of democratizing access to complex disease genetic results.
Date Issued
2023-04-04
Date Acceptance
2023-02-28
Citation
Cell Metabolism, 2023, 35 (4), pp.695-710.e6
ISSN
1550-4131
Publisher
Cell Press
Start Page
695
End Page
710.e6
Journal / Book Title
Cell Metabolism
Volume
35
Issue
4
Copyright Statement
© 2023 The Author(s). Published by Elsevier Inc.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36963395
PII: S1550-4131(23)00079-7
Subjects
Access to Information
Diabetes Mellitus, Type 2
Genomics
Humans
Phenotype
Prospective Studies
CMDKP
data sharing
diabetes
effector genes
genetic associations
genetic support
genomics
GWAS
portal
T2DKP
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2023-03-23