Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.
Date Issued
2020-06-29
Date Acceptance
2020-05-20
Citation
Seminars in Immunopathology, 2020, 42, pp.469-486
ISSN
1863-2297
Publisher
Springer Science and Business Media LLC
Start Page
469
End Page
486
Journal / Book Title
Seminars in Immunopathology
Volume
42
Copyright Statement
© The Author(s) 2020. This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format,
as long as you give appropriate credit to the original author(s) and the
source, provide a link to the Creative Commons licence, and indicate
if changes were made. The images or other third party material in this
article are included in the article's Creative Commons licence, unless
indicated otherwise in a credit line to the material. If material is not
included in the article's Creative Commons licence and your intended
use is not permitted by statutory regulation or exceeds the permitted
use, you will need to obtain permission directly from the copyright
holder. To view a copy of this licence, visit http://creativecommons.
org/licenses/by/4.0/.
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format,
as long as you give appropriate credit to the original author(s) and the
source, provide a link to the Creative Commons licence, and indicate
if changes were made. The images or other third party material in this
article are included in the article's Creative Commons licence, unless
indicated otherwise in a credit line to the material. If material is not
included in the article's Creative Commons licence and your intended
use is not permitted by statutory regulation or exceeds the permitted
use, you will need to obtain permission directly from the copyright
holder. To view a copy of this licence, visit http://creativecommons.
org/licenses/by/4.0/.
License URL
Sponsor
March of Dimes
Identifier
https://link.springer.com/article/10.1007%2Fs00281-020-00801-4
Grant Number
22-FY18-821
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Pathology
Galectins
Preterm birth
Microbial infections
Glycans
TRICHOMONAS-VAGINALIS LIPOPHOSPHOGLYCAN
MATERNAL-FETAL INTERFACE
GALACTOSIDE-BINDING LECTINS
PLACENTAL PROTEIN 13
TOLL-LIKE RECEPTORS
DIFFERENTIAL GLYCOSYLATION
INTRAUTERINE INFECTION
EXTRACELLULAR-MATRIX
SINGLETON PREGNANCY
ENDOTHELIAL-CELLS
Galectins
Glycans
Microbial infections
Preterm birth
Immunology
1103 Clinical Sciences
Publication Status
Published
Date Publish Online
2020-06-29