Prevalence and population attributable risk for chronic airflow obstruction in a large multinational study
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Rationale: The Global Burden of Disease programme identified smoking, and ambient and household air pollution as the main drivers of death and disability from Chronic Obstructive Pulmonary Disease (COPD). Objective: To estimate the attributable risk of chronic airflow obstruction (CAO), a quantifiable characteristic of COPD, due to several risk factors. Methods: The Burden of Obstructive Lung Disease study is a cross-sectional study of adults, aged≥40, in a globally distributed sample of 41 urban and rural sites. Based on data from 28,459 participants, we estimated the prevalence of CAO, defined as a post-bronchodilator one-second forced expiratory volume to forced vital capacity ratio < lower limit of normal, and the relative risks associated with different risk factors. Local RR were estimated using a Bayesian hierarchical model borrowing information from across sites. From these RR and the prevalence of risk factors, we estimated local Population Attributable Risks (PAR). Measurements and Main Results: Mean prevalence of CAO was 11.2% in men and 8.6% in women. Mean PAR for smoking was 5.1% in men and 2.2% in women. The next most influential risk factors were poor education levels, working in a dusty job for ≥10 years, low body mass index (BMI), and a history of tuberculosis. The risk of CAO attributable to the different risk factors varied across sites. Conclusions: While smoking remains the most important risk factor for CAO, in some areas poor education, low BMI and passive smoking are of greater importance. Dusty occupations and tuberculosis are important risk factors at some sites.
Date Issued
2021-06-01
Date Acceptance
2020-11-09
Citation
American Journal of Respiratory and Critical Care Medicine, 2021, 203 (11), pp.1353-1365
ISSN
1073-449X
Publisher
American Thoracic Society
Start Page
1353
End Page
1365
Journal / Book Title
American Journal of Respiratory and Critical Care Medicine
Volume
203
Issue
11
Copyright Statement
© 2020 American Thoracic Society, All Rights Reserved.
Sponsor
Wellcome Trust
Grant Number
085790/Z/08/Z
Subjects
Burden of Obstructive Lung Disease (BOLD) study
Chronic airflow obstruction
Multinational study
Population attributable risk
Respiratory System
11 Medical and Health Sciences
Publication Status
Published
Date Publish Online
2020-11-10