Type I interferons in tuberculosis: Foe and occasionally friend
File(s)
Author(s)
Moreira-Teixeira, Lúcia
Mayer-Barber, Katrin
Sher, Alan
O'Garra, Anne
Type
Journal Article
Abstract
Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection. Type I interferons (IFN) regulate a broad family of genes that either stimulate or inhibit immune function, having both host-protective and detrimental effects, and exhibit well-characterized antiviral activity. Transcriptional studies have uncovered a potential deleterious role for type I IFN in active tuberculosis. Since then, additional studies in human tuberculosis and experimental mouse models of M. tuberculosis infection support the concept that type I IFN promotes both bacterial expansion and disease pathogenesis. More recently, studies in a different setting have suggested a putative protective role for type I IFN. In this study, we discuss the mechanistic and contextual factors that determine the detrimental versus beneficial outcomes of type I IFN induction during M. tuberculosis infection, from human disease to experimental mouse models of tuberculosis.
Date Issued
2018-05-07
Date Acceptance
2018-03-29
Citation
Journal of Experimental Medicine, 2018, 215 (5), pp.1273-1285
ISSN
0022-1007
Publisher
Rockefeller University Press
Start Page
1273
End Page
1285
Journal / Book Title
Journal of Experimental Medicine
Volume
215
Issue
5
Copyright Statement
© 2018 Moreira-Teixeira et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29666166
PII: jem.20180325
Subjects
11 Medical And Health Sciences
Immunology
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2018-04-17