Challenges associated with interpreting mechanisms of AF
File(s)
Accepted version
Author(s)
Roney, Caroline H
Wit, Andrew L
Peters, Nicholas S
Type
Journal Article
Abstract
Determining optimal treatment strategies for complex arrhythmogenesis in AF is confounded by the lack of consensus regarding the mechanisms causing AF. Studies report different mechanisms for AF, ranging from hierarchical drivers to anarchical multiple activation wavelets. Differences in the assessment of AF mechanisms are likely due to AF being recorded across diverse models using different investigational tools, spatial scales and clinical populations. The authors review different AF mechanisms, including anatomical and functional re-entry, hierarchical drivers and anarchical multiple wavelets. They then describe different cardiac mapping techniques and analysis tools, including activation mapping, phase mapping and fibrosis identification. They explain and review different data challenges, including differences between recording devices in spatial and temporal resolutions, spatial coverage and recording surface, and report clinical outcomes using different data modalities. They suggest future research directions for investigating the mechanisms underlying human AF.
Date Issued
2020-03-01
Date Acceptance
2019-11-18
Citation
Arrhythmia & electrophysiology review, 2020, 8 (4), pp.273-284
ISSN
2050-3369
Publisher
Taylor & Francis
Start Page
273
End Page
284
Journal / Book Title
Arrhythmia & electrophysiology review
Volume
8
Issue
4
Copyright Statement
© 2020 The Author(s). This work is open access under the CC-BY-NC 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/legalcode) which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.
Sponsor
British Heart Foundation
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000518840800006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
RG/16/3/32175
Subjects
Science & Technology
Life Sciences & Biomedicine
Peripheral Vascular Disease
Cardiovascular System & Cardiology
AF
cardiac arrhythmia mechanisms
anatomical re-entry
functional re-entry
hierarchical drivers
triggered activity
anarchical multiple wavelets
PULMONARY VEIN ISOLATION
PERSISTENT ATRIAL-FIBRILLATION
CATHETER ABLATION
FOCAL IMPULSE
DOMINANT FREQUENCY
PHASE SINGULARITY
LEADING CIRCLE
SPIRAL WAVES
ROTORS
CONDUCTION
Publication Status
Published
Date Publish Online
2020-03-01