The Mtb-HIV syndemic interaction: why treating M. tuberculosis infection may be crucial for HIV-1 eradication
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Accelerated tuberculosis and AIDS progression seen in HIV-1 and Mycobacterium tuberculosis (Mtb)-coinfected individuals indicates the important interaction between these syndemic pathogens. The immunological interaction between HIV-1 and Mtb has been largely defined by how the virus exacerbates tuberculosis disease pathogenesis. Understanding of the mechanisms by which pre-existing or subsequent Mtb infection may favor the replication, persistence and progression of HIV, is less characterized. We present a rationale for the critical consideration of ‘latent’ Mtb infection in HIV-1 prevention and cure strategies. In support of this position, we review evidence of the effect of Mtb infection on HIV-1 acquisition, replication and persistence. We propose that ‘latent’ Mtb infection may have considerable impact on HIV-1 pathogenesis and the continuing HIV-1 epidemic in sub-Saharan Africa.
Date Issued
2020-03-24
Date Acceptance
2020-02-13
Citation
Future Virology, 2020, 15 (2), pp.101-126
ISSN
1746-0794
Publisher
Future Medicine
Start Page
101
End Page
126
Journal / Book Title
Future Virology
Volume
15
Issue
2
Copyright Statement
© 2020 Anna Coussens.
This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000523650700005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Virology
AIDS
granuloma
HIV-1 cure
immune activation
latency
transmission
tuberculosis
viral expansion
viral reservoir
HUMAN-IMMUNODEFICIENCY-VIRUS
CD4(+) T-CELLS
TUMOR-NECROSIS-FACTOR
LONG TERMINAL REPEAT
MYCOBACTERIUM-TUBERCULOSIS
LATENT TUBERCULOSIS
VIRAL LOAD
PULMONARY TUBERCULOSIS
FACTOR-ALPHA
SET-POINT
Publication Status
Published
Date Publish Online
2020-03-24