From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research"
Author(s)
Type
Journal Article
Abstract
In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia-reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.
Date Issued
2016-10-14
Date Acceptance
2016-10-04
Citation
Basic Research in Cardiology, 2016, 111 (6)
ISSN
0300-8428
Publisher
Springer Verlag
Journal / Book Title
Basic Research in Cardiology
Volume
111
Issue
6
Copyright Statement
© The Author(s) 2016. Open Access.
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/27743118
PII: 10.1007/s00395-016-0586-x
Subjects
Cardiomyocyte signaling pathways
Cardioprotection
Cardiovascular disease
Co-morbidities
Drug targeting
Endothelial permeability
Extracellular RNA (eRNA)
Heart regeneration
Induced pluripotent stem cells
Ischemia–reperfusion injury
Lipid metabolism
MicroRNAs (miRNAs)
Mitochondria
Remote ischemic conditioning
Publication Status
Published
Coverage Spatial
Germany
Article Number
69