Nervous system regionalization entails axial allocation before neural differentiation
Author(s)
Type
Journal Article
Abstract
Neural induction in vertebrates generates a CNS that extends the rostral-caudal length of the body. The prevailing view is that neural cells are initially induced with anterior (forebrain) identity; caudalizing signals then convert a proportion to posterior fates (spinal cord). To test this model, we used chromatin accessibility to define how cells adopt region-specific neural fates. Together with genetic and biochemical perturbations, this identified a developmental time window in which genome-wide chromatin-remodeling events preconfigure epiblast cells for neural induction. Contrary to the established model, this revealed that cells commit to a regional identity before acquiring neural identity. This “primary regionalization” allocates cells to anterior or posterior regions of the nervous system, explaining how cranial and spinal neurons are generated at appropriate axial positions. These findings prompt a revision to models of neural induction and support the proposed dual evolutionary origin of the vertebrate CNS.
Date Issued
2018-11-01
Date Acceptance
2018-09-19
Citation
Cell, 2018, 175 (4), pp.1105-1118.e17
ISSN
0092-8674
Publisher
CELL PRESS
Start Page
1105
End Page
1118.e17
Journal / Book Title
Cell
Volume
175
Issue
4
Copyright Statement
© 2018 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449100600021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
EMBRYONIC STEM-CELLS
CHICK-EMBRYO
MOUSE EMBRYO
SPINAL-CORD
HOX GENES
MESODERM SPECIFICATION
OVERLAPPING FUNCTIONS
REGULATORY ELEMENTS
T BRACHYURY
HINDBRAIN
Publication Status
Published
Date Publish Online
2018-10-18