Acoustic Manipulation of Bio-Particles at High Frequencies: An Analytical and Simulation Approach
File(s)
Published version
Author(s)
Samandari, M
Abrinia, K
Sanati-Nezhad, A
Type
Journal Article
Abstract
Manipulation of micro and nano particles in microfluidic devices with high resolution
is a challenge especially in bioengineering applications where bio-particles (BPs) are separated or
patterned. While acoustic forces have been used to control the position of BPs, its theoretical aspects
need further investigation particularly for high-resolution manipulation where the wavelength
and particle size are comparable. In this study, we used a finite element method (FEM) to amend
analytical calculations of acoustic radiation force (ARF) arising from an imposed standing ultrasound
field. First, an acoustic solid interaction (ASI) approach was implemented to calculate the ARF
exerted on BPs and resultant deformation induced to them. The results were then used to derive a
revised expression for the ARF beyond the small particle assumption. The expression was further
assessed in numerical simulations of one- and multi-directional standing acoustic waves (SAWs).
Furthermore, a particle tracing scheme was used to investigate the effect of actual ARF on separation
and patterning applications under experimentally-relevant conditions. The results demonstrated a
significant mismatch between the actual force and previous analytical predictions especially for high
frequencies of manipulation. This deviation found to be not only because of the shifted ARF values
but also due to the variation in force maps in multidirectional wave propagation. Findings of this
work can tackle the simulation limitations for spatiotemporal control of BPs using a high resolution
acoustic actuation.
is a challenge especially in bioengineering applications where bio-particles (BPs) are separated or
patterned. While acoustic forces have been used to control the position of BPs, its theoretical aspects
need further investigation particularly for high-resolution manipulation where the wavelength
and particle size are comparable. In this study, we used a finite element method (FEM) to amend
analytical calculations of acoustic radiation force (ARF) arising from an imposed standing ultrasound
field. First, an acoustic solid interaction (ASI) approach was implemented to calculate the ARF
exerted on BPs and resultant deformation induced to them. The results were then used to derive a
revised expression for the ARF beyond the small particle assumption. The expression was further
assessed in numerical simulations of one- and multi-directional standing acoustic waves (SAWs).
Furthermore, a particle tracing scheme was used to investigate the effect of actual ARF on separation
and patterning applications under experimentally-relevant conditions. The results demonstrated a
significant mismatch between the actual force and previous analytical predictions especially for high
frequencies of manipulation. This deviation found to be not only because of the shifted ARF values
but also due to the variation in force maps in multidirectional wave propagation. Findings of this
work can tackle the simulation limitations for spatiotemporal control of BPs using a high resolution
acoustic actuation.
Date Issued
2017-09-27
Date Acceptance
2017-09-21
Citation
Micromachines, 2017, 8 (10)
ISSN
2072-666X
Publisher
MDPI AG
Journal / Book Title
Micromachines
Volume
8
Issue
10
Copyright Statement
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
License URL
Publication Status
Published
Article Number
290
Date Publish Online
2017-09-27