Dear Spiral user, We’re pleased to introduce Helix, https://helix.imperial.ac.uk/ Imperial’s new repository for research datasets. Please use Helix for all future dataset deposits. There is no change to Spiral - continue depositing as usual. For queries, contact the Research Data Management team at rdm-enquiries@imperial.ac.uk. Kind regards, the Spiral Team. The Spiral team
Exosomes: From potential culprits to new therapeutic promise in the setting of cardiac fibrosis
File(s)
cells-09-00592-v2.pdf (2.4 MB)
Published version
OA Location
Author(s)
Tikhomirov, Roman
Donnell, Benedict Reilly-O'
Catapano, Francesco
Faggian, Giuseppe
Gorelik, Julia
Type
Journal Article
Abstract
Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease. Cardiac fibroblasts and myofibroblasts are the main effectors of ECM deposition and scar formation. The heart is a complex multicellular organ, where the various resident cell types communicate between themselves and with cells of the blood and immune systems. Exosomes, which are small extracellular vesicles, (EVs), contribute to cell-to-cell communication and their pathophysiological relevance and therapeutic potential is emerging. Here, we will critically review the role of endogenous exosomes as possible fibrosis mediators and discuss the possibility of using stem cell-derived and/or engineered exosomes as anti-fibrotic agents.
Date Issued
2020-03-02
Date Acceptance
2020-02-27
Citation
Cells, 2020, 9 (3)
URI
DOI
ISSN
2073-4409
Publisher
MDPI AG
Journal / Book Title
Cells
Volume
9
Issue
3
Copyright Statement
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Sponsor
British Heart Foundation
British Heart Foundation
British Heart Foundation
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32131460
PII: cells9030592
Grant Number
RG/17/13/33173
FMDY1548246 (ORCA #56436)
RM/17/3/33381
Subjects
EVs engineering
cardiac fibrosis
exosomes
extracellular vesicle (EVs)
heart failure
microRNAs
noncoding RNAs
stem cells
Publication Status
Published
Coverage Spatial
Switzerland
Date Publish Online
2020-03-02