Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity
Author(s)
De Silva, A
Bloom, SR
Type
Journal Article
Abstract
The global obesity epidemic has resulted in significant morbidity and mortality. However, the medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but carries signifi cant perioperative risks. The gut hormones, peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1), are elevated following gastric bypass and have been shown to reduce food intake. They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed.
Date Issued
2012-01-01
Date Acceptance
2011-07-19
Citation
Gut and Liver, 2012, 6 (1), pp.10-20
ISSN
2005-1212
Publisher
The Editorial Office of Gut and Liver
Start Page
10
End Page
20
Journal / Book Title
Gut and Liver
Volume
6
Issue
1
Copyright Statement
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
Medical Research Council (MRC)
Grant Number
G7811974
Subjects
Science & Technology
Life Sciences & Biomedicine
Gastroenterology & Hepatology
GASTROENTEROLOGY & HEPATOLOGY
Gut hormones
Appetite
Peptide tyrosine tyrosine
Glucagon-like peptide 1
Obesity
GLUCAGON-LIKE PEPTIDE-1
CENTRAL-NERVOUS-SYSTEM
Y GASTRIC BYPASS
FOOD-INTAKE
NEUROPEPTIDE-Y
WEIGHT-LOSS
ENERGY-EXPENDITURE
GLYCEMIC CONTROL
DIABETES-MELLITUS
FEEDING-BEHAVIOR
Publication Status
Published