Oxidative stress-related biomarkers in multiple sclerosis: a review
Author(s)
Type
Journal Article
Abstract
Aim: To provide an up-to-date review of oxidative stress biomarkers in multiple sclerosis and thus identify candidate molecules with greatest promise as biomarkers of diagnosis, disease activity or prognosis. Method: A semi-systematic literature search using PubMed and other databases. Results: Nitric oxide metabolites, superoxide dismutase, catalase, glutathione reductase, inducible nitric oxide synthase, protein carbonyl, 3-nitrotyrosine, isoprostanes, malondialdehyde and products of DNA oxidation have been identified across multiple studies as having promise as diagnostic, therapeutic or prognostic markers in MS. Conclusion: Heterogeneity of study design, particularly patient selection, limits comparability across studies. Further cohort studies are needed, and we would recommend promising markers be incorporated into future clinical trials to prospectively validate their potential.
Date Issued
2016-08
Date Acceptance
2016-05-25
Citation
Biomarkers in Medicine, 2016, 10 (8), pp.889-902
ISSN
1752-0363
Publisher
Future Medicine
Start Page
889
End Page
902
Journal / Book Title
Biomarkers in Medicine
Volume
10
Issue
8
Subjects
Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
biomarkers
diagnosis
disability progression
disease activity
multiple sclerosis
oxidative stress
reactive oxygen species
therapeutic monitoring
GLUTATHIONE-PEROXIDASE ACTIVITY
NITRIC-OXIDE METABOLITES
CEREBROSPINAL-FLUID NITRITE
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
LIPID-PEROXIDATION
SUPEROXIDE-DISMUTASE
NITRATE LEVELS
INFLAMMATORY MARKERS
DISEASE PROGRESSION
CATALASE ACTIVITY
Publication Status
Published
Date Publish Online
2016-07-14