Tailoring mechanical properties of sol-gel hybrids for bone regeneration through polymer structure
File(s)
Accepted version
Author(s)
Chung, J
Li, S
Stevens, MM
Georgiou, T
Jones, JR
Type
Journal Article
Abstract
Bioglass was the first synthetic biomaterial that formed a chemical bond to bone. Although bioactive glass scaffolds can mimic bone’s porous structure, they are brittle. Sol–gel derived hybrids could overcome this problem because their nanoscale conetworks of silica and organic polymer have the potential to provide unique physical properties and controlled homogeneous biodegradation. Copolymers of methyl methacrylate (MMA) and 3-(trimethoxysilyl)propyl methacrylate (TMSPMA) have been used as an organic source for hybrids to take advantage of their self-hardening property. However, the effect of well-defined poly(MMA-co-TMSPMA) architecture in the hybrid system has not been investigated. Here, linear, randomly branched, and star shaped methacrylate based copolymers were synthesized via reversible addition–fragmentation chain transfer (RAFT) polymerization method. These copolymers were then used to fabricate hybrids. The 3-D polymer structure had a significant effect on mechanical properties, providing higher strain to failure while maintaining a compressive strength similar to sol–gel glass. Star copolymer–SiO2 hybrids had a modulus of toughness 9.6-fold greater and Young’s modulus 4.5-fold lower than a sol–gel derived bioactive glass. During in vitro cell culture, MC3T3-E1 osteoblast precursor cells adhered on the surface regardless of the polymer structure. Introducing star polymers to inorganic–organic hybrids opens up possibilities for the fine-tuning physical properties of bone scaffold materials.
Date Issued
2016-09-13
Date Acceptance
2016-08-01
Citation
Chemistry of Materials, 2016, 28 (17), pp.6127-6135
ISSN
1520-5002
Publisher
American Chemical Society
Start Page
6127
End Page
6135
Journal / Book Title
Chemistry of Materials
Volume
28
Issue
17
Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemistry of Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acs.chemmater.6b01941
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Grant Number
EP/M019950/1
EP/K020641/1
Subjects
Science & Technology
Physical Sciences
Technology
Chemistry, Physical
Materials Science, Multidisciplinary
Chemistry
Materials Science
NANOCOMPOSITES THIN-FILMS
STAR POLYMERS
POLY(METHYL METHACRYLATE)
GROWTH BEHAVIOR
BIOACTIVE GLASS
ARCHITECTURE
SCAFFOLDS
ELABORATION
FABRICATION
COPOLYMERS
03 Chemical Sciences
09 Engineering
Materials
Publication Status
Published
Date Publish Online
2016-08-18