CD57+ memory T cells proliferate in vivo
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent antigenic stimulation. We used in vivo deuterium labeling and ex vivo analyses of telomere length, telomerase activity, and intracellular expression of the cell-cycle marker Ki67 to distinguish between two non-exclusive scenarios: (i) CD57+memory T cells do not proliferate and instead arise via phenotypic transition from the CD57−memory T cell pool; and/or (ii) CD57+memory T cells self-renew via intracompartmental proliferation. Our results provide compelling evidence in favor of the latter scenario and further suggest in conjunction with mathematical modeling that self-renewal isby far the most abundant source of newly generated CD57+memory T cells. Immunological memory therefore appears to be intrinsically sustainable among highly differentiated subsets of T cells that express CD57.
Date Issued
2020-12-15
Date Acceptance
2020-10-14
Citation
Cell Reports, 2020, 33 (11), pp.e1-e5
ISSN
2211-1247
Publisher
Elsevier
Start Page
e1
End Page
e5
Journal / Book Title
Cell Reports
Volume
33
Issue
11
Copyright Statement
© 2020 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Sponsor
Wellcome Trust
European Commission Directorate-General for Research and Innovation
Identifier
https://www.sciencedirect.com/science/article/pii/S221112472031490X?via%3Dihub
Grant Number
103865/Z/14/Z
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
TELOMERE LENGTH
LIFE-SPAN
SUBSETS
LYMPHOCYTES
EXPRESSION
ANTIGEN
CYTOMEGALOVIRUS
INFECTION
KINETICS
SURVIVAL
Enter keywords here
0601 Biochemistry and Cell Biology
1116 Medical Physiology
Publication Status
Published
Date Publish Online
2020-12-15