A Bayesian approach to estimate changes in condom use from limited human immunodeficiency virus prevalence data
Author(s)
Dureau, J
Kalogeropoulos, K
Vickerman, P
Pickles, M
Boily, M-C
Type
Journal Article
Abstract
Evaluation of large-scale intervention programmes against human immunodeficiency virus (HIV) is becoming increasingly important, but impact estimates frequently hinge on knowledge of changes in behaviour such as the frequency of condom use over time, or other self-reported behaviour changes, for which we generally have limited or potentially biased data. We employ a Bayesian inference methodology that incorporates an HIV transmission dynamics model to estimate condom use time trends from HIV prevalence data. Estimation is implemented via particle Markov chain Monte Carlo methods, applied for the first time in this context. The preliminary choice of the formulation for the time varying parameter reflecting the proportion of condom use is critical in the context studied, because of the very limited amount of condom use and HIV data available. We consider various novel formulations to explore the trajectory of condom use over time, based on diffusion-driven trajectories and smooth sigmoid curves. Numerical simulations indicate that informative results can be obtained regarding the amplitude of the increase in condom use during an intervention, with good levels of sensitivity and specificity performance in effectively detecting changes. The application of this method to a real life problem demonstrates how it can help in evaluating HIV interventions based on a small number of prevalence estimates, and it opens the way to similar applications in different contexts.
Date Issued
2016-02-01
Date Acceptance
2015-05-01
Citation
Journal of the Royal Statistical Society Series C - Applied Statistics, 2016, 65 (2), pp.237-257
ISSN
0035-9254
Publisher
Wiley
Start Page
237
End Page
257
Journal / Book Title
Journal of the Royal Statistical Society Series C - Applied Statistics
Volume
65
Issue
2
Copyright Statement
© 2015 The Authors Journal of the Royal Statistical Society: Series C Applied Statistics
Published by John Wiley & Sons Ltd on behalf of the Royal Statistical Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use,
distribution and reproduction in any medium, provided the original work is properly cited.
The copyright line for this article was changed on 6th January after original online publication.
Published by John Wiley & Sons Ltd on behalf of the Royal Statistical Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use,
distribution and reproduction in any medium, provided the original work is properly cited.
The copyright line for this article was changed on 6th January after original online publication.
License URL
Subjects
Science & Technology
Physical Sciences
Statistics & Probability
Mathematics
Bayesian inference
Condom use
Epidemic modelling
Human immunodeficiency virus infections
Particle Markov chain Monte Carlo methods
Time varying parameter
FEMALE SEX WORKERS
HIV-PREVENTION PROGRAM
MODELING ANALYSIS
SOUTHERN INDIA
HIV/AIDS EPIDEMIC
GROWTH CURVE
IMPACT
INTERVENTIONS
TRANSMISSION
CLIENTS
Publication Status
Published