Challenges and opportunities for computer-aided molecular and process design approaches in advancing sustainable pharmaceutical manufacturing
File(s)
Published version
Author(s)
Adjiman, Claire S
Galindo, Amparo
Type
Journal Article
Abstract
Pharmaceutical manufacturing gives rise to a large amount of waste per kilogram of active ingredient, a growing concern with the trend towards larger therapeutic molecules. Achieving better sustainability requires new approaches to process development. We explore the role that computer-aided molecular (and process) design (CAMPD) methods can play, highlighting the value of an end-to-end design mindset that can enable a more holistic assessment of sustainability. We discuss the challenges that must be overcome to deploy such an approach, identifying new structure-property models and the integration of CAMPD with process synthesis and computer-aided synthesis planning as possible research directions.
Date Issued
2025-03-01
Date Acceptance
2025-01-01
Citation
Current Opinion in Chemical Engineering, 2025, 47
ISSN
2211-3398
Publisher
Elsevier
Journal / Book Title
Current Opinion in Chemical Engineering
Volume
47
Copyright Statement
© 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Subjects
Biotechnology & Applied Microbiology
CHEMISTRY RESEARCH AREAS
CRYSTALLIZATION
Engineering
Engineering, Chemical
FRAMEWORK
Life Sciences & Biomedicine
PERSPECTIVE
Science & Technology
SELECTION
SOLVENT DESIGN
Technology
Publication Status
Published
Article Number
101073
Date Publish Online
2025-01-11