Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation
Author(s)
Type
Journal Article
Abstract
A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.
Date Issued
2015-07-15
Date Acceptance
2015-04-23
Citation
Advanced Materials, 2015, 27 (27), pp.4006-4012
ISSN
0935-9648
Publisher
Wiley
Start Page
4006
End Page
4012
Journal / Book Title
Advanced Materials
Volume
27
Issue
27
Copyright Statement
© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
License URL
Identifier
https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201501351
Subjects
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
high throughput
human pluripotent stem cells
materials discovery
polymer microarrays
stem cell differentiation
DEFINED CONDITIONS
SELF-RENEWAL
LAMININ ISOFORMS
GROWTH
BIOMATERIALS
CARDIOMYOCYTES
DERIVATION
RECEPTOR
SUPPORT
CULTURE
Publication Status
Published
Date Publish Online
2015-06-01