Composite hydrogel: A high fidelity soft tissue mimic for surgery
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Published version
Author(s)
Tan, Zhengchu
Dini, Daniele
Rodriguez y Baena, Ferdin
Forte, Antonio
Type
Journal Article
Abstract
Accurate tissue phantoms are difficult to design due to the complex non-linear viscoelastic properties of real soft tissues. A composite hydrogel, resulting from a mix of poly(vinyl) alcohol and phytagel, is able to reproduce the viscoelastic responses of different soft tissues due to its compositional tunability. The aim of this work is to demonstrate the flexibility of the composite hydrogel in mimicking the interactions between surgical tools and various soft tissues, such as brain, lung and liver. Therefore compressive stiffness, insertion forces and frictional forces were used as matching criteria to determine the hydrogel compositions for each soft tissue. A full map of the behaviour of the synthetic material is provided for these three characteristics and the compositions found to best match the mechanical response of brain, lung and liver are reported. The optimised hydrogel samples are then tested and shown to mimic the behaviour of the three tissues with unprecedented fidelity. The effect of each hydrogel constituent on the compressive stiffness, needle insertion and frictional forces is also detailed in this work to explain their individual contributions and synergistic effects. This study opens important opportunities for the realisation of surgical planning and training devices and tools for in-vitro tissue testing.
Date Issued
2018-12-15
Date Acceptance
2018-10-12
Citation
Materials and Design, 2018, 160, pp.886-894
ISSN
0264-1275
Publisher
Elsevier
Start Page
886
End Page
894
Journal / Book Title
Materials and Design
Volume
160
Copyright Statement
© 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (
http://creativecommons.org/licenses/by/4.0/
)
http://creativecommons.org/licenses/by/4.0/
)
License URL
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Grant Number
EP/N025954/1
Subjects
Science & Technology
Technology
Materials Science, Multidisciplinary
Materials Science
Composite hydrogel
Soft tissue
Tissue mimic
Surgery
Material properties
BRAIN-TISSUE
SUBSTRATE STIFFNESS
IN-VITRO
PHANTOM
BIOCOMPATIBILITY
ELASTOGRAPHY
RESIDENTS
CELLS
LIVER
MODEL
0912 Materials Engineering
0913 Mechanical Engineering
Materials
Publication Status
Published
Date Publish Online
2018-10-12