Indications and results of systemic to pulmonary shunts: results from a national database
File(s)SPS indications Dorobantu revision unmarked.docx (1.24 MB)
Accepted version
Author(s)
Dorobantu, Dan Mihai
Pandey, Ragini
Sharabiani, Mansour Taghavi
Mahani, Alireza Shahidzadeh
Angelini, Gianni Davide
Type
Journal Article
Abstract
OBJECTIVES
The systemic-to-pulmonary shunt (SPS) remains an important palliative therapy in many congenital heart defects. Unlike other surgical treatments, the mortality after shunt operations has risen. We used an audit dataset to investigate potential reasons for this change and to report national results.
METHODS
A total of 1993 patients classified in 13 diagnoses underwent an SPS procedure between 2000 and 2013. Indication trends by era and also results before repair or next stage are reported. A dynamic hazard model with competing risks and modulated renewal was used to determine predictors of outcomes.
RESULTS
The usage of SPS in Tetralogy of Fallot (ToF) has significantly decreased in the last decade, with cases of single ventricle (SV) and pulmonary atresia (PA) with septal communication increasing (P < 0.001 for trends). This is correlated with an increase of early mortality from 5.1% in the first half of the decade to 9.8% in the latter (P = 0.007 for trend). At 1.5 years, 13.9% of patients have died, 17.8% had a shunt reintervention and 68.3% of patients are alive and reintervention-free. Low weight, PA-intact septum, SV and central shunt type are among the factors associated with increased mortality, whereas PA-ventricular septal defect, corrected transposition, isomerism, central shunt and low weight are among those associated with increased reintervention, also having a dynamic effect on the relative risk when compared with ToF patients. Shunt reinterventions are not associated with worse outcomes when adjusted by other covariates, but they do have higher 30-day mortality if occurring earlier than 30 days from the index (P < 0.001). Patients operated in later years were found to have significantly lower survival at a distance from index.
CONCLUSIONS
The observed historical rise in mortality for shunt operations relates to complex factors including changing practice for repair of ToF and for univentricular palliation. PA and SV patients are the groups of patients at the highest risk of death. Small size, shunt type and underlying anatomical defect are the main determinants of outcomes. Trends in indication and mortality seem to indicate that more severely ill patients benefit from shunting, but with an increase in mortality.
The systemic-to-pulmonary shunt (SPS) remains an important palliative therapy in many congenital heart defects. Unlike other surgical treatments, the mortality after shunt operations has risen. We used an audit dataset to investigate potential reasons for this change and to report national results.
METHODS
A total of 1993 patients classified in 13 diagnoses underwent an SPS procedure between 2000 and 2013. Indication trends by era and also results before repair or next stage are reported. A dynamic hazard model with competing risks and modulated renewal was used to determine predictors of outcomes.
RESULTS
The usage of SPS in Tetralogy of Fallot (ToF) has significantly decreased in the last decade, with cases of single ventricle (SV) and pulmonary atresia (PA) with septal communication increasing (P < 0.001 for trends). This is correlated with an increase of early mortality from 5.1% in the first half of the decade to 9.8% in the latter (P = 0.007 for trend). At 1.5 years, 13.9% of patients have died, 17.8% had a shunt reintervention and 68.3% of patients are alive and reintervention-free. Low weight, PA-intact septum, SV and central shunt type are among the factors associated with increased mortality, whereas PA-ventricular septal defect, corrected transposition, isomerism, central shunt and low weight are among those associated with increased reintervention, also having a dynamic effect on the relative risk when compared with ToF patients. Shunt reinterventions are not associated with worse outcomes when adjusted by other covariates, but they do have higher 30-day mortality if occurring earlier than 30 days from the index (P < 0.001). Patients operated in later years were found to have significantly lower survival at a distance from index.
CONCLUSIONS
The observed historical rise in mortality for shunt operations relates to complex factors including changing practice for repair of ToF and for univentricular palliation. PA and SV patients are the groups of patients at the highest risk of death. Small size, shunt type and underlying anatomical defect are the main determinants of outcomes. Trends in indication and mortality seem to indicate that more severely ill patients benefit from shunting, but with an increase in mortality.
Date Issued
2016-06-01
Date Acceptance
2015-11-17
Citation
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2016, 49 (6), pp.1553-1563
ISSN
1010-7940
Publisher
OXFORD UNIV PRESS INC
Start Page
1553
End Page
1563
Journal / Book Title
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
Volume
49
Issue
6
Copyright Statement
© The Author 2016. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. This is a pre-copy-editing, author-produced version of an article accepted for publication in European Journal of Cardio-Thoracic Surgery following peer review. The definitive publisher-authenticated version Dan Mihai Dorobantu, Ragini Pandey, Mansour Taghavi Sharabiani, Alireza Shahidzadeh Mahani, Gianni Davide Angelini, Robin Peter Martin, Serban Constantin Stoica, Indications and results of systemic to pulmonary shunts: results from a national database, European Journal of Cardio-Thoracic Surgery, Volume 49, Issue 6, June 2016, Pages 1553–1563, is available online at: https://doi.org/10.1093/ejcts/ezv435
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000378498700004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Respiratory System
Surgery
Cardiovascular System & Cardiology
Systemic-to-pulmonary shunt
Pulmonary atresia
Tetralogy of Fallot
Indication trends
Blalock- Taussig shunt
BLALOCK-TAUSSIG SHUNT
RISK-FACTORS
MORTALITY
PALLIATION
Publication Status
Published
Date Publish Online
2016-01-13