Transmission-blocking effects of primaquine and methylene blue suggest P. falciparum gametocyte sterilisation rather than effects on sex ratio
File(s)
Author(s)
Type
Journal Article
Abstract
Gametocyte density and sex-ratio can predict the proportion of mosquitoes that become infected after feeding on blood of patients receiving non-gametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex-ratio, mosquito feeding experiments are required to demonstrate their early transmission-blocking effects.
Date Issued
2019-10-15
Date Acceptance
2019-02-01
Citation
Clinical Infectious Diseases, 2019, 69 (8), pp.1436-1439
ISSN
1058-4838
Publisher
Oxford University Press (OUP)
Start Page
1436
End Page
1439
Journal / Book Title
Clinical Infectious Diseases
Volume
69
Issue
8
Copyright Statement
© 2019 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/cid/ciz134.
Sponsor
PATH-Program for Appropriate Technology in Health
Medical Research Council (MRC)
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30753355
PII: 5316265
Grant Number
GAT.0888-30-01618462-COL
MR/R015600/1
Subjects
anopheles
infectiousness
malaria
transmission
treatment
Microbiology
06 Biological Sciences
11 Medical and Health Sciences
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2019-02-12