KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19
Author(s)
Type
Journal Article
Abstract
Ly49+CD8+ T cells are a subset of CD8+ T cells that show immunoregulatory activity in mice. Li et al. report the existence of a similar CD8+ T cell subset in humans that expresses killer cell immunoglobulin-like receptors (KIRs), a functional parallel of the mouse Ly49 family (see the Perspective by Levescot and Bensussan). These cells, which can suppress self-reactive CD4+ T cells, were more abundant in patients with autoimmune conditions such as celiac disease, multiple sclerosis, and lupus, as well as in patients infected with influenza virus or severe acute respiratory syndrome coronavirus 2. When mice selectively deficient in Ly49+CD8+ T cells were infected with viruses, they showed normal antiviral immune responses but eventually developed symptoms of autoimmune disease. KIR+CD8+ T cells may therefore be an important therapeutic target for the control of autoimmune diseases such as “long COVID” that emerge after viral infections. —STS
Date Issued
2022-04-15
Date Acceptance
2022-03-01
Citation
Science, 2022, 376 (6590), pp.265-265
ISSN
0036-8075
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Start Page
265
End Page
265
Journal / Book Title
Science
Volume
376
Issue
6590
Copyright Statement
Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
https://creativecommons.org/licenses/by/4.0/
This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000783317900042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
CELIAC-DISEASE
EXPRESS
INSIGHTS
LANDSCAPE
Multidisciplinary Sciences
NK
PHENOTYPE
RECEPTOR
RNA-SEQ
Science & Technology
Science & Technology - Other Topics
Publication Status
Published
Article Number
eabi9591
Date Publish Online
2022-04-15