System-wide approaches to antimicrobial therapy and antimicrobial resistance in the UK: the AMR-X framework
File(s)
Published version
Author(s)
AMR-X Collaborators
Type
Journal Article
Abstract
Antimicrobial resistance (AMR) threatens human, animal, and environmental health. Acknowledging the urgency of addressing AMR, an opportunity exists to extend AMR action-focused research beyond the confines of an isolated biomedical paradigm. An AMR learning system, AMR-X, envisions a national network of health systems creating and applying optimal use of antimicrobials on the basis of their data collected from the delivery of routine clinical care. AMR-X integrates traditional AMR discovery, experimental research, and applied research with continuous analysis of pathogens, antimicrobial uses, and clinical outcomes that are routinely disseminated to practitioners, policy makers, patients, and the public to drive changes in practice and outcomes. AMR-X uses connected data-to-action systems to underpin an evaluation framework embedded in routine care, continuously driving implementation of improvements in patient and population health, targeting investment, and incentivising innovation. All stakeholders co-create AMR-X, protecting the public from AMR by adapting to continuously evolving AMR threats and generating the information needed for precision patient and population care.
Date Issued
2024-05-01
Date Acceptance
2024-01-05
Citation
The Lancet Microbe, 2024, 5 (5), pp.e500-e507
ISSN
2666-5247
Publisher
Elsevier
Start Page
e500
End Page
e507
Journal / Book Title
The Lancet Microbe
Volume
5
Issue
5
Copyright Statement
© 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/38461831
PII: S2666-5247(24)00003-X
Subjects
Animals
Anti-Bacterial Agents
Anti-Infective Agents
Antimicrobial Stewardship
Drug Resistance, Bacterial
Drug Resistance, Microbial
Humans
United Kingdom
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2024-03-07