Bacterial vaccine antigen discovery in the reverse vaccinology 2.0 era: progress and challenges
File(s)
Published version
Author(s)
Bidmos, FA
Siris, S
Gladstone, Camilla
Langford, PR
Type
Journal Article
Abstract
The ongoing, and very serious, threat from antimicrobial resistance necessitates the development and use of preventative measures, predominantly vaccination. Polysaccharide-based vaccines have provided a degree of success in limiting morbidity from disseminated bacterial infections, including those caused by the major human obligate pathogens, Neisseria meningitidis and Streptococcus pneumoniae. Limitations of these polysaccharide vaccines, such as partial coverage and induced escape leading to persistence of disease, provide a compelling argument for the development of protein vaccines. In this review, we briefly chronicle approaches that have yielded licensed vaccines before highlighting reverse vaccinology 2.0 and its potential application in the discovery of novel bacterial protein vaccine candidates. Technical challenges and research gaps are also discussed.
Date Issued
2018-10-08
Date Acceptance
2018-09-17
Citation
Frontiers in Immunology, 2018, 9
ISSN
1664-3224
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Immunology
Volume
9
Copyright Statement
© 2018 Bidmos, Siris, Gladstone and Langford. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Sponsor
Meningitis Now
Identifier
http://www.imperial.ac.uk/people/f.bidmos
Grant Number
N/A
Subjects
reverse vaccinology 2.0
Human monoclonal antibodies
protein vaccines
Bacterial Infections
Immunotherapeutic agents
Publication Status
Published
Coverage Spatial
United Kingdom
Article Number
2315